呼吸科产耐药酶肺炎克雷伯菌感染的危险因素分析-第三军医大学学报.PDFVIP

呼吸科产耐药酶肺炎克雷伯菌感染的危险因素分析 1 1 1 1 1 1 2 3 陈愉生 ，林晓红 , 华志丹 ，李鸿茹 , 涂洵崴 , 俞梅娥 , 胡辛兰 , 姚秀钦 【摘要】 目的：探讨呼吸科产耐药酶肺炎克雷伯菌感染的危险因素分析。方法：收集福建省立医院呼吸科 2009 年1 月1 日-2013 年12 月31 日确诊为医院内感染肺炎克雷伯菌的住院患者资料共121 例，分为产耐 2 药酶的病例组41 例和未产耐药酶的对照组80 例，通过单因素t 检验、χ检验及多因素 logistic 回归分 2 析，分析各研究因素与产耐药酶肺炎克雷伯菌的关系,找出感染危险因素。结果：经单因素 t 检验和χ检 验发现，年龄、住院时间、调整住院时间、感染前使用抗生素种数、感染前使用第一代头孢、感染前使用 第三代头孢均与呼吸科感染产耐药酶肺炎克雷伯菌有关；多因素 logistic回归分析发现，年龄大、住院时 间长是独立危险因素。结论：年龄大、住院时间长的住院患者为主要高危人群，应根据此危险因素采取有 效措施预防呼吸科产耐药酶肺炎克雷伯菌的感染。 【关键词】 呼吸科；医院感染；产耐药酶；肺炎克雷伯菌；危险因素； 中图分类号 R378 文献标识码A Study for the risk factors for infection with Klebsiella pneumoniae producing antibiotic-resistant enzymes in the respiratory department CHEN Yusheng, LIN Xiaohong, HUA Zhidan, LI Hongru, Tu Xunwei, Yu Meie, Hu Xinlan, Yao Xiuqin Fujian Provincial Hospital, Fuzhou, Fujian 350001, China Abstract: OBJECTIVE To evaluate the risk factors for infection with Klebsiella pneumoniae producing antibiotic-resistant enzymes in the respiratory department. METHODS From 1 January 2009 to 31 December 2013 , 121 cases of nosocomial infection caused by Klebsiella pneumoniae were analyzed. The case group was the patients who had suffered from Klebsiella pneumoniae producing antibiotic-resistant enzymes. The control group was those who had suffered from bacteria producing no antibiotic-resistant enzymes. With t-test, Chi-square test and multivariate Logistic regression, we analyzed the relationship between each factor and infection with Klebsiella pneumoniae producing antibiotic-resistant enzymes to find out the r