神经节苷脂对急性CO中毒迟发性脑病患者血清NSE的影响.docVIP

精品论文 参考文献 神经节苷脂对急性CO中毒迟发性脑病患者血清NSE的影响 武莉娜1 许国栋2 黄艳芬1 冯素萍1(通讯作者) 靳玫1 　　(1新乡医学院第三附属医院神经内科 河南新乡 453003) 　　(2新乡医学院第三附属医院神经外科 河南新乡 453003) 　　 　　【摘要】目的:探讨神经节苷脂对急性CO中毒后迟发性脑病（DEACMP）患者血清神经元特异性烯酶化酶（NSE）的影响。方法:收治急性一氧化碳中毒迟发性脑病患者60例随机分成2组，治疗组和对照组各30例，对照组给予常规治疗，治疗组则在常规治疗基础上加用 神经节苷脂，所有患者均在急性期入院3天内抽取血标本进行NSE测定，治疗30天后再次采取标本复查，对比分析治疗前后NSE的变化。结果:治疗后两组患者血清NSE均较治疗前下降，治疗组下降尤为显著，差异有统计学意义。结论:神经节苷脂能降低急性CO中毒迟发性脑病患者血清NSE水平，对治疗DEACMP有效。 　　【关键词】神经节苷脂 急性一氧化碳中毒迟发性脑病 NSE 　　【中图分类号】R749.1 【文献标识码】A 【文章编号】1672-5085（2013）44-0164-02 　　【Abstract】Objective:To investigate effect of ganglioside curing delayed encephalopathy after acute carbon monoxide poisoning（DEACMP）on serum levels of neuronspecific Enolase(NSE).Methods: 60 DEACMP patients were divided into control group 30 and treatment group 30 in random. Control group was treated with supportive and hyperbaric oxygen treatment,treatment group was treated with ganglioside in addition.Fasting venous blood in all patients with DEACMP was drawn within 3 days after attack,and NSE levels were measured.Samples were drawn again and measured after treatment of 30 days.Make a comparative analysis on the changes of NSE before and after treatment.Results：After treatment the NSE levels in serum of all patients were decreased than that before treatment, The treatment group decreased more significantly, the difference was statistically significant.Conclusion：Ganglioside can decrease the NSE level in patients with DEACMP,and it is effective in treating DEACMP. 　　【Key words】 ganglioside DEACMP NSE 　　一氧化碳中毒迟发性脑病是指急性一氧化碳中毒在意识障碍恢复后，经过2～60d的“假愈期”后出现的神经精神障碍症候群［1］，致残率高，目前尚无有效的治疗方法。本文着重探究神经节苷脂对DEACMP患者血清NSE的影响，从而为治疗DEACMP提供新的思路。 　　1 资料和方法 　　1.1 一般资料 病例选取我院2011-2013年收治的门诊及住院急性CO中毒患者60例，均符合DEACMP的诊断标准，治疗组30例，男17例、女13例，年龄14～83岁，平均55.3岁，昏迷时间3-47h，假愈期3-60d；对照组30例，男15例、女15例，年龄16～78岁，平均50.5岁，昏迷时间2-45h，假愈期3-64d。两组性别、年龄、昏迷时间、假愈期无显著性差异，具有可比性。 　　1.2治疗方法 对照组给予常规治疗，包括高压氧、减轻脑水肿、清除自由基、营养脑细胞及改善脑循环药物治疗。治疗组在此基础上给予神经节苷脂