神经节苷酯联合高压氧治疗病毒性脑炎脑损伤的临床疗效观察.docVIP

精品论文 参考文献 神经节苷酯联合高压氧治疗病毒性脑炎脑损伤的临床疗效观察 姚莉萍 杨剑文 徐玉艳 杨期明 南华大学附属湖南省老年医院神经内科 湖南省长沙市 410016 　　【摘 要】目的 观察单唾液酸四己糖神经节苷脂（神经节苷酯）联合高压氧治疗病毒性脑炎脑损伤的临床疗效。方法 选取我院病毒性脑炎患者48 例，随机分为常规组和治疗组。常规组采用基础治疗+高压氧治疗，治疗在常规组基础上加用神经节苷酯。治疗后的临床疗效通过脑电图、美国国立卫生研究院卒中量表( NIHSS) 、简易智能精神量表（MMSE）进行评价。结果 治疗后常规组患者脑电图异常率37.5%，治疗组患者脑电图异常率12.5%，治疗组异常率比常规组低，差异有统计学意义（Plt;0.05）；两组患者治疗后的NIHSS 评分降低、MMSE 评分提高，治疗组比常规组改善更明显，差异有统计学意义(Plt;0.05)。 　　结论 神经节苷酯对病毒性脑炎脑损伤治疗有一定的疗效，值得进一步在临床上使用。 　　【关键词】神经节苷酯；高压氧；病毒性脑炎脑损伤；临床疗效Clinical Effects of Ganglioside with hyperbaric oxygen on Treating Viral Encephalitis of Brain InjuryYao Li-ping，Yang Jian-wen，Xu Yu-yan，etal.（Department of Neurology, Affiliated The Old Hospital of Hunan Province，University of South China，Changsha，Hunan 410016，China）Abstract: Objective A systematic observation was conducted on the clinical effects of ganglioside with hyperbaric oxygen on treatingviral encephalitis of brain injury . Methods A number of 48 sufferers of this disease were randomly divided into a contrast group and atreatment group. The contrast group received basic treatment and a therapy of hyperbaric oxygen, while the treatment group took basictreatment and ganglioside. The clinical efficacy was assessed by using EEG, American NationalInstitutes of Health Stroke Scale (NIHSS), Mini Mental Scale (MMSE) aftertreatment. Results It showed that the percentage of abnormality was 37.5% for the contrast group after the treatment, and 12.5% forthe treatment group. The abnormal rate of treatment group was lower than in the contrast group. The difference was statistically significant(Plt;0.05). The two groups after treatment in patients had lower NIHSS score, MMSE score increased, the treatment group improved moreobviously than the contrast group, the difference was statistically significant (Plt;0.05). Conclusion It concluded that ganglioside has somecertain effects on treating viral encephalitis of brain injury and thus can be further applied clinically .Key words: ganglioside；Hyperbaric oxygen；viral en