丙泊酚及靶控输注系统PPT.ppt

TCI and Propofol(丙泊酚及靶控输注系统);I’ve consulted for propofol(我为丙泊酚做过顾问) AstraZeneca I’ve consulted for remifentanil(我为瑞芬太尼做顾问) Glaxo, Abbott I’ve consulted for companies interested in TCI(我为对靶控输注系统感兴趣的公司顾问) Alaris, B Braun, Medex;Pharmacokinetic Concepts(药代动力学概念);Volume of Distribution(分布容积);Clearance(清除率);三室模型 ;Opioid Half-Lives (minutes)(鴉片類製劑的半衰期 --分钟);Opioid Pharmacokinetics(鴉片類製劑药代动力学);Context-Sensitive Half-Time(时效相关半衰期);Propofol Pharmacokinetics(丙泊酚 药代动力学);50% effect site decrement curves(效应部位浓度50%衰减曲线);Propofol/opioid vs. isoflurane/opioid(丙泊酚/鴉片類製劑 vs.异氟醚/鴉片類製劑) ;丙泊酚 药代动力学;Target Controlled Infusion靶控输注系统;TCI Solves the Differential Equations for Drug Concentration (靶控输注系统解决了药物浓度的微分方程) ;First Generation TCI(第一代靶控输注系统)Target = Plasma(以血浆为靶部位);CATIA: 第一靶控输注系统 (Schwilden et al, Bonn);“Diprifusor” 第一商业靶控输注系统 …;TCI Variability(靶控输注系统的变异性);TCI Can Reduce Variability(靶控输注系统能减少变异性);Second Generation TCI(第二代 靶控输注系统)Target = Effect Site(效应部位为靶部位);STANPUMP 靶控输注系统 (Shafer, Stanford);0;Three compartment model with effect site(三室模型与效应部位);Fentanyl TCI, Plasma Target(芬太尼TCI，血浆靶浓度);0;0;0;Are Drug Models Predictiveof Drug Effect?(药物模型能预测药物效应吗?);Conscious/Unconscious Prediction (Pk)(意识清楚/无意识的预测);Are drug models predictive?(药物模型有预测性吗?);Third Generation TCI靶控输注系统Closed Loop Effect Site Control(闭合回路 效应部位 控制);RUGLOOP (De Smet, Struys,Ghent);Closed Loop Control of Propofol(闭合回路控制丙泊酚);Over 500 peer-reviewed articles in Medline as of September 2006(至2006 年9月，Medline有超过500篇相关的同行评论文章)Approved everywhere except in the US(除美国以外均可使用) ;UK IRELAND BELGIUM FRANCE NORWAY SWEDEN DENMARK NETHERLANDS GERMANY AUSTRIA;药量指南;丙泊酚/瑞芬太尼;Thank You;谢谢