络活喜和非洛地平干预老年高血压患者100例疗效观察.docVIP

精品论文 参考文献 络活喜和非洛地平干预老年高血压患者100例疗效观察 殷大梅 　　（江苏省苏州市工业园区胜浦医院内科 215126） 　　【摘要】目的 观察络活喜和非洛地平对老年体检人群清晨血压的影响。方法 将本院行清晨体检的老年人群100例随机分为治疗组(52例)和对照组(48例)。其中，治疗组患者给予络活喜5 mg/d，q.d.，口服；对照组给予非洛地平5 mg，q.d.，口服。14 d 为1个疗程。2组患者均停用其它降压药物。观察2组患者14 d、28 d后的清晨血压、心率、甘油三酯(TG)和总胆固醇(TC)变化情况，比较2组治疗后临床有效率和不良反应发生率。结果 2组治疗14 d和28 d后，收缩压、舒张压、心率、TG和TC显著降低(P＜0.01)，且治疗组比对照组下降显著，除心率外，其它各指标变化比较均有显著意义(P＜0.05或P＜0.01)。治疗组治疗后有效率为96.15(50/52)，显著高于对照组的77.08%(37/48)。此外，治疗组和对照组的不良反应发生率分别为13.46%和18.75%，比较无显著差异(P＞0.05)。结论 络活喜和非洛地平都能降低高血压患者清晨血压水平而不影响心率，副作用小，但络活喜效果更优。 　　【关键词】 体检人群 清晨血压 疗效观察 　　【中图分类号】R969 【文献标识码】A 【文章编号】2095-1752（2014）08-0037-02 　　Clinical observation of morning blood pressure in elderly examination population: a report of 100 cases 　　【Abstract】 Objective To observe the influence of Luohuoxi and felodipine on blood pressure of elderly examination population in the early morning. Methods A total of 100 elderly patients with hypertension were randomly divided into control group (48 cases) given oral felodipine, 5 mg, q.d., and treatment group (52 cases) given oral Luohuoxi, 5 mg/d, q.d., 14 d as one course. Other antihypertensive drugs were withdrawn in both groups. Blood pressure changes, heart rate, triglyceride (TG) and total cholesterol (TC) on day 14 and 28 in both groups were observed, while clinical response rate (RR) and rate of adverse reactions were compared. Results After 14-d and 28-d treatment, systolic pressure, diastolic pressure, TG and TC decreased evidently (P＜0.01), and they were obviously lower in treatment group than in control group (P＜0.05 or P＜0.01), but no apparent change was observed in both groups. The clinical RR and rate of adverse reactions in treatment group were 96.15% and 13.46%, and the RR was markedly higher than that in control group (77.08%), and the difference was significant (P＜0.01), whereas there was no significant difference in adverse reactions (P＞0.05). Conclusion Luohuoxi and felodipine