羧甲司坦片对慢性阻塞性肺疾病急性加重期祛痰作用的临床观察.docVIP

精品论文 参考文献 羧甲司坦片对慢性阻塞性肺疾病急性加重期祛痰作用的临床观察 遵义市第一人民医院 急诊科 贵州遵义 563000 摘要：目的 观察羧甲司坦片对慢性阻塞性肺疾病急性加重期的祛痰作用及肺功能的影响。方法 60例COPD急性发作期患者随机分为对照组30例采用吸氧、抗感染、止咳化痰、维持水电解质平衡等综合治疗，治疗组30例在对照组基础上加用羧甲司坦片0.5g每天口服三次，治疗1周，观察两组的临床疗效及肺功能的变化。结果 治疗组在改善痰液性状、痰量、咳嗽症状及综合临床疗效与对照组差异有统计学意义（plt;0.05），而在改善咳嗽难易程度和肺部啰音方面两组差异无统计学意义（pgt;0.05）；治疗组FEV1/FVC、FEV1、FVC、PEF、RV及RV/TLC改善程度明显优于对照组（Plt;0.05）。结论 羧甲司坦片在治疗AECOPD患者中其化痰祛痰作用的临床疗效肯定，且改善患者的肺功能。 关键词：羧甲司坦片；慢性阻塞性肺疾病；肺功能 [Abstract]Objectives：To investigate the carbocisteine tablets effect of fudosteine tablets on acute exacerbation of chronic obstructive pulmonary disease（AECOPD）.Methods：60 inpatients with acute exacerbation of COPD were randomly divided into treatment group（n=30）and control groups（n=30）.Both groups received comprehensive treatment containing oxygen inhalation，antibiotics，facilitating expectoration，suppressing cough and maintaining balance of water and electrolyte.Treatment group were additionally treated with carbocisteine tablets 0.5g per os three times daily for 1 week.The effect of elimination phlegm and lung function changes in two groups were observed before and after treatment.Results：There were significantly difference of the character of sputum，volume，cough and clinical comprehensive effect in treatment group than control group（plt;0.05）.There was no significant difference of difficulty in expectoration and rale in the lung between the two groups（pgt;0.05）.The improved levels of FEV1/FVC，FEV1，FVC，PEF，RV and RV/TLC were significantly increased in treatment group than control group（plt;0.05）.Conclusions：Fodusteine tablet is effective used in AECOPD and it can improve lung function. [Key Words]Carbocisteine tablets；AECOPD；lung function； 羧甲司坦（羧甲基半胱氨酸、化痰片）属于口服黏液溶解药，可改变痰多黏蛋白浓度，加强呼吸道纤毛运动，口服后可促进排痰。另外，慢性阻塞性肺疾病与肺部对有害颗粒和气体的异常炎性反应相关，本品有抗炎作用，可减轻呼吸道炎症反应，组织修补增强，被广泛应用于急、慢性呼吸系统疾病的患者。慢性阻塞性肺疾病急性加重期的主要表现之一是咳嗽咳痰、痰量增多及痰的性状改变。因此祛痰治疗对于慢性阻塞性肺疾病急性加重（acute exacerbation of chronic obstructive pulmonary disease，AECOPD）患者尤为重要。我科采用羧甲司坦片口服联合常规治疗COPD 急性加重期患