奈米表面粗糙度对左心室导管内皮化之研究.PDFVIP

行政院國家科學委員會專題研究計畫 成果報告 奈米表面粗糙度對左心室導管內皮化之研究 計畫類別：個別型計畫 計畫編號：NSC92-2314-B-002-246- 執行期間：92年08月01日至93年07月31日 執行單位：國立臺灣大學醫學院外科 計畫主持人：王水深 共同主持人：鍾次文 計畫參與人員：王水深，鍾次文 ，潘勁屹，李喬賓 報告類型：精簡報告 處理方式：本計畫可公開查詢 中 華 民 93年11月2日 國 Enhancement the Growth of Human Endothelial Cells by Surface Roughness at Nanometer Scale a b Shoei-Shen Wang , Tze-Wen Chung Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan, ROC a Department of Chemical Engineering National Yunlin University of Science Technology b Abstract their blood compatibility. Various methods have been developed to support the seeding and This study investigated whether a nano-meter growth of endothelial cells (HUVECs) on PU or scale of surface roughness could improve the other biomaterial surfaces such as surface adhesion and growth of human endothelial cells modifications by plasma treatment and on biomaterial surface. Different molecular photochemically grafted GRGD peptide on weights or chain lengths of polyethylene glycol modified PU surface or chitosan surface by this (PEG) were mixed and then grafted to group [1-3]. polyurethane (PU) surface, a model smooth In regard to roughness of surface in affecting surface, to form a nano-meter (nm) scale of the growth of different kinds of cells, some roughness for PU-PEG surfaces (PU-PEG