原发性中枢神经系统血管炎 PPT.pptVIP

Primary angiitis of the central nervous system;Definition;Pathology;临床分型：GACNS, BACNS, Atypical PACNS ;;;Nikolov NP et al. (2006) Diagnosis and treatment of vasculitis of the central nervous system in a patient with systemic lupus erythematosus Nat Clin Pract Rheumatol 2: 627–633 doi:10.1038/ncprheum0337;CSF: 中度淋巴细胞和蛋白升高，非感染性血管炎表现。;Treatment;The End;A: T2 Profound signal abnormalities in the white matter are compatible with ischemic or demyelinating disease. B: FLAIR The white matter signal abnormalities are more obvious. C: DW No frank restricted diffusion is seen, militating against acute/subacute infarction. D: Enhanced T1 striking enhancement along the perivascular regions (arrows) and slightly along the meninges. There is no fusiform, nodular, or ring-like enhancement as would be expected with demyelinating disease. E: Enhanced coronal T1 section through the trigones of the lateral ventricles shows dramatic perivascular enhancement (arrows).;Leptomeningeal arteries show severe transmural inflammation with lumen obliteration (asterisk).