耳后注射甲泼尼龙琥珀酸钠治疗急性低频感音神经性聋的疗效观察.docVIP

精品论文 参考文献 耳后注射甲泼尼龙琥珀酸钠治疗急性低频感音神经性聋的疗效观察 无锡市第三人民医院耳鼻咽喉科 江苏 无锡 214041 　　［摘要］　目的：探讨耳后注射甲泼尼龙琥珀酸钠治疗急性低频感音神经性聋的疗效。方法：41例急性低频感音神经性聋患者随机分为观察组和对照组，观察组（21例）在耳后局部注射甲泼尼龙琥珀酸钠40mg，给药1次/2d，给药三次为一疗程。对照组（20例）口服泼尼松1mg/kg，晨起一次性顿服，连用3d，有疗效，则延长使用2d。结果：1个疗程治疗后，耳后注射组治愈13例，显效3例，有效2例，无效3例，总有效率85.71%；口服激素组治愈13例，显效3例，有效1例，无效3例，总有效率85.00%。两组组内治疗前后比较差异均有统计学意义（p﹤0.5），组间比较差异无统计学意义（p﹥0.5），两组间总有效率差异无统计学意义（p﹥0.5）。结论：耳后注射甲泼尼龙琥珀酸钠治疗急性低频感音神经性聋，疗效确切，操作简便，全身副作用较少，是一种较安全简单的治疗方法。 　　［关键词］听觉丧失，感音神经性；耳后注射；甲泼尼龙琥珀酸钠 　　［中图分类号］R764.437　　［文献标志码］A 　　Clincal observation on the treatment of the acute low-tone sensorineural hearing loss with postaurical injection of methylperdinisolone sodium succinate 　　Song Jun, The Third Peoplersquo;s Hospital of Wuxi,Wuxi,Jiangsu,214041,China 　　［Abstract］Objective: To discuss the clinical efficacy on the treatment of the acute low-tone sensorineural hearing loss (ALHL) with postaurical injection of methylperdinisolone sodium succinate. Method: 41 cases of ALHL were randomly divided into the observation group and the control group. The observation group (21cases) were given the postaurical injection of methylperdinisolone sodium succinate，40mg/2d. The control group(20cases) received the oral prednisone,1mg/mg/d, administrated once on the morning for 3d, if effective, prolonging for another 2d. Result: The total effective rate was 85.71% in observation group and 85.00% in control group. There was no significant difference between the two groups (pgt;0.5). Conclusion: Postaurical injection of methylperdinisolone sodium succinate for the acute low-tone sensorineural hearing loss is effective, simple and without obvious side effect, which may be a safe and simple treatment. 　　［Key words］ hearing loss，sensorneural；postaurical injection；methylperdinisolone sodium succinate. 　　急性低频感音神经性聋（acute low-tone sensorineural hearing loss，ALHL）是一种原因不明、急性起病的、以低频听力下降为主的感音神经性聋，可伴有低音调耳鸣、耳内闷胀感，病情可反复发作[1]。推测膜迷路积水是其病理基础，因此糖皮质激素、脱水剂为主要治疗手段。但全身使用糖皮质激素副作用较大，尤其是对伴有高血压、糖尿病的年老患者，经鼓室给药因为是有创操作，可导致鼓膜穿孔、感染、