毒理学相关资料,第七章内容参考文献16.pdfVIP

Am J Physiol Gastrointest Liver Physiol 280: G805–G811, 2001. Kupffer cell-derived cyclooxygenase-2 regulates hepatocyte Bcl-2 expression in choledocho-venous fistula rats ENRICO O. SOUTO,1 HIDEYUKI MIYOSHI,1 RAYMOND N. DUBOIS,2 AND GREGORY J. GORES1 1 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905; and 2Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 Received 11 August 2000; accepted in final form 13 November 2000 Souto, Enrico O., Hideyuki Miyoshi, Raymond N. over, transduction of hepatocytes with Bcl-2 expressing Dubois, and Gregory J. Gores. Kupffer cell-derived cyclo- adenovirus vectors also protects hepatocytes from is- oxygenase-2 regulates hepatocyte Bcl-2 expression in chole- chemia-reperfusion injury (1). These data suggest that docho-venous fistula rats. Am J Physiol Gastrointest Liver strategies to induce endogenous expression of Bcl-2 in Physiol 280: G805–G811, 2001.—We have previously dem- hepatocytes could potentially prove therapeutically onstrated that after bile duct ligation hepatocytes express useful in the treatment of human liver diseases. Bcl-2, although the mechanisms regulating Bcl-2 expression We (13) have previously demonstrated de novo he- were not identified. Our aim was to determine if biliary constituents induce hepatocellular expression of Bcl-2 by a patocyte expression of Bcl-2 in the bile duct-ligated rat, cyclooxygenase-2 (COX-2)-dependent mechanism. We used