毒理学相关资料,第五章内容参考文献12.pdfVIP

Toxicology Letters ELSEVIER Toxicology Letters 80 (I 995) I- 18 Review Article Comparative efficacy and toxicity of desferrioxamine, deferiprone and other iron and aluminium chelating drugs George J. Kontoghiorghes* Department of Haematology. Royal Free Hospital School of Medicine. University of London, Pond St, London N W3 2QG, UK Received 4 August 1994;accepted 30 April 1995 Abstract The efficacy and toxicity aspects of the iron and aluminium chelating drugs desferrioxamine and deferiprone (Ll, 1,2- dimethyl-3-hydroxypyrid-4-one), have been compared. Major emphasis was given in the use of these two and also of other chelators in conditions of iron overload, imbalance and toxicity, as well as the incidence and possible causes of toxic side effects in both animals and humans. The chemical basis of chelation and the interaction of these chelators with the iron pools are discussed within the context of clinical application in iron overload and other conditions such as renal dialysis, rheumatoid arthritis, cancer, heart disease, malaria, etc. The design and development of new orally active a-ketohydroxypyridine and other chelators are considered and compared with 14 other chelators which have been previously