毒理学相关资料,第五章内容参考文献23.pdfVIP

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毒理学相关资料,第五章内容参考文献23.pdf

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毒理学相关资料,第五章内容参考文献23

TOXICOLOGICAL SCIENCES 64, 28–40 (2001) Copyright © 2001 by the Society of Toxicology The Role of Oxidative Stress in Indium Phosphide-Induced Lung Carcinogenesis in Rats Barbara C. Gottschling,* Robert R. Maronpot,† James R. Hailey,† Shyamal Peddada,† Cindy R. Moomaw,† James E. Klaunig,* and Abraham Nyska†,1 *Indiana University School of Medicine, Division of Toxicology, Department of Pharmacology and Toxicology, 635 Barnhill Drive, MS 1021, Indianapolis, Indiana 46202; and †National Institute of Environmental Health Sciences, Laboratory of Experimental Pathology, 111 T. W. Alexander Drive, MD B3-06, Research Triangle Park, North Carolina 27709 Received February 26, 2001; accepted June 14, 2001 used extensively in the microelectronics industry to manufac- Indium phosphide (IP), widely used in the microelectronics ture semiconductors, injection lasers, solar cells, photodiodes, industry, was tested for potential carcinogenicity. Sixty male and and light-emitting diodes and have been proposed as replace- 60 female Fischer 344 rats were exposed by aerosol for 6 h/day, 5 3 ments for silicon in computer microchips (Blazka et al., 1994). days/week, for 21 weeks (0.1 or 0.3 mg/m ; stop exposure groups) or 105 weeks (0 or 0.03 mg/m3 groups) with interim groups (10 Because of its recent widespread usage, IP was selected for animals/group/sex) evaluated at 3 months. After 3-month expo- chronic toxicity investigations by the National Toxi