毒理学相关资料,第五章内容参考文献3.pdfVIP

Free Radical Biology Medicine, Vol. 29, Nos. 3/4, pp. 231–240, 2000 Copyright © 2000 Elsevier Science Inc. Printed in the USA. All rights reserved 0891-5849/00/$–see front matter PII S0891-5849(00)00300-2 Lars Ernster Commemorative Issue Guest Editors: Enrique Cadenas and Kelvin J. A. Davies PERSUASIVE EVIDENCE THAT QUINONE REDUCTASE TYPE 1 (DT DIAPHORASE) PROTECTS CELLS AGAINST THE TOXICITY OF ELECTROPHILES AND REACTIVE FORMS OF OXYGEN ALBENA T. DINKOVA-KOSTOVA and PAUL TALALAY Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA (Received 18 April 2000; Accepted 26 April 2000) Abstract—An extensive body of evidence supports the conclusion that by catalyzing obligatory two-electron reductions of quinones to hydroquinones, NAD(P)H:quinone reductase (QR1) protects cells against the deleterious effects of redox cycling of quinones, their ability to deplete glutathione, and to produce neoplasia. The effects of elevation of QR1 levels by various enzyme inducers, inhibition of the enzyme by dicumarol, and genetic deletion of the enzyme (knockout mouse) are all consistent with the proposed protective fun