毒理学相关资料,第五章内容参考文献34.pdfVIP

TOXICOLOGICAL SCIENCES 62, 353–359 (2001) Copyright © 2001 by the Society of Toxicology Favism: Effect of Divicine on Rat Erythrocyte Sulfhydryl Status, Hexose Monophosphate Shunt Activity, Morphology, and Membrane Skeletal Proteins David C. McMillan, 1 Laura J. C. Bolchoz, and David J. Jollow Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425 Received April 3, 2001; accepted May 17, 2001 and isouramil, as the probable causative agents based on their Favism is an acute anemic crisis that can occur in susceptible ability to deplete reduced glutathione (GSH) in isolated sus- individuals who ingest fava beans. The fava bean pyrimidine pensions of human G6PD-deficient red cells (Mager et al., aglycone divicine has been identified as a hemotoxic constituent; 1965). Divicine and isouramil are not present in fava beans per however, its mechanism of toxicity remains unknown. We have shown recently that divicine can induce a favic-like response in se, but are aglycones of the biologically inactive fava bean rats and that divicine is directly toxic to rat red cells. In the present -glucosides, vicine, and convicine, respectively. study, we have examined the effect of hemotoxic concentrations of The mechanism underlying the onset of favism is not yet divicine on rat erythrocyte sulfhydryl status, hexose monophos- understood. However, it has been