毒理学相关资料,第五章内容参考文献42.pdfVIP

Chemico-Biological Interactions 130–132 (2001) 247–260 locatechembiont Three different stable human breast adenocarcinoma sublines that overexpress ALDH3A1 and certain other enzymes, apparently as a consequence of constitutively upregulated gene transcription mediated by transactivated EpREs (electrophile responsive elements) present in the 5-upstream regions of these genes Lakshmaiah Sreerama, Norman E. Sla´dek * Department of Pharmacology, Medical School, Academic Health Center, Uniersity of Minnesota, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA Abstract ALDH3A1 catalyzes the detoxification of cyclophosphamide, mafosfamide, 4-hydroperox- ycyclophosphamide and other oxazaphosphorines. Constitutive ALDH3A1 levels, as well as those of certain other drug-metabolizing enzymes, e.g. NQO1 and CYP1A1, are relatively low in cultured, relatively oxazaphosphorine-sensitive, human breast adenocarcinoma MCF- - Abbreiations: ALDH3A1 and ALDH1A1 (formerly ALDH-3 and ALDH-1, respectively), human cytosolic aldehyde dehydrogenases; AKR1C1, aldo-keto reductase 1C1 (also referred to as dihydrodiol dehydrogenase 1 and as 20-hydroxysteroid dehydrogenase); NQO1, NAD(P)H:quinone oxidoreductase 1 (less specifically, also referred to as DT-diaphorase or DT-D); EpRE, electrophile responsive element (also referred to as an antioxidant responsive element or ARE); CYP1A1, cytochrome P4501A1; XRE, xenobiotic responsive element (also referred to as a dioxin responsive element or DRE, and as an aryl hydrocarbon responsive element or AhRE); GST, glutathione S-transferase; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; G6PDH; glucose-6-phosphate dehydroge