毒理学相关资料,第五章内容参考文献44.pdfVIP

Free Radical Biology Medicine, Vol. 25, No. 3, pp. 346–361, 1998 Copyright © 1998 Elsevier Science Inc. Printed in the USA. All rights reserved 0891-5849/98 $19.00 .00 PII S0891-5849(98)00067-7 Review Article REDOX SIGNALS AND NF-B ACTIVATION IN T CELLS MARGARET E. GINN-PEASE and RONALD L. WHISLER Division of Immunology, Department of Internal Medicine and Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA (Received 8 September 1997; Revised 7 January 1998; Re-revised 25 February 1998; Accepted 11 March 1998) Abstract—Accumulating data from a number of laboratories have recently indicated that the response of transcription factor NF-B to alterations in the redox homeostasis of cells may play an important role in modulating immune function. The activation of NF-B has been recognized to regulate a number of genes necessary for normal T cell responses including IL-2, IL-6, IL-8, and several T cell surface receptors. Diminished NF-B activity has been shown to occur in T cells with aging, suggesting that impaired activation of NF-B might occur during cellular senescence. In addition, aberrancies in NF-B activity have been implicated in the immunopathog