毒理学相关资料,第五章内容参考文献2.pdfVIP

MARCH 2000 VOLUME 13, NUMBER 3 © Copyright 2000 by the American Chemical Society Invited Review Role of Quinones in Toxicology† Judy L. Bolton,*,‡ Michael A. Trush,§ Trevor M. Penning, Glenn Dryhurst,⊥ and Terrence J. Monks*,@ Department of Medicinal Chemistry and Pharmacognosy (M/C 781), College of Pharmacy, The University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612-7231, Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Johns Hopkins University, 615 North Wolfe Street, Baltimore, Maryland 21205, Department of Pharmacology, University of Pennsylvania School of Medicine, University of Pennsylvania, 3620 Hamilton Walk, Philadelphia, Pennsylvania 19104-6084, Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, and Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712-1074 Received December 20, 1999 Quinones represent a class of toxicological intermediates which can create a variety of hazardous effects in vivo, including acute cytotoxicity, immunotoxicity, and carcinogenesis. The mechanisms by which quinones cause these effects can be quite complex. Quinones are Michael acceptors, and cellular damage can occur through alkylation of crucial cellular proteins and/or DNA. Alternatively, quinones are highly redox active molecules which can redox cycle with their semiquinone radicals, leading to format