毒理学相关资料,第四章内容参考文献3.pdfVIP

下载本文档

2
0
约3.61万字
约 4页
2018-01-24 发布于浙江
举报
版权申诉

毒理学相关资料,第四章内容参考文献3.pdf

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

毒理学相关资料,第四章内容参考文献3

0090-9556/01/2904-570–573$3.00 DRUG METABOLISM AND DISPOSITION Vol. 29, No. 4, Part 2 Copyright © 2001 by The American Society for Pharmacology and Experimental Therapeutics 290123/894077 DMD 29:570–573, 2001 Printed in U.S.A. IMPLICATIONS OF POLYMORPHIC CYTOCHROME P450-DEPENDENT DRUG METABOLISM FOR DRUG DEVELOPMENT MAGNUS INGELMAN-SUNDBERG Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden This paper is available online at ABSTRACT: The main part of human cytochrome P450-dependent drug metab- preclinical emphasis and involves combinatorial chemistry in con- olism is carried out by polymorphic enzymes that can cause abol- junction with high-throughput-based analysis of thousands of sub- ished, quantitatively or qualitatively altered, or enhanced drug me- stances with respect to their absorption, metabolism, and excre- tabolism. Ultrarapid metabolism is due to stable duplication, tion characteristics. The outcome is that companies drop multiduplication, or amplification of active genes. Several exam- substrates for polymorphic enzymes at an early stage in develop- ples exist where subjects carrying certain alleles suffer from a lack ment, which will of course create fewer problems with polymorphic of drug efficacy due to ultrarapid metabolism or, alternatively, en