舒肝解郁胶囊治疗广泛性焦虑障碍的临床研究.docVIP

精品论文 参考文献 舒肝解郁胶囊治疗广泛性焦虑障碍的临床研究 乔云栓 张士巧通讯作者 崔卫东 李 丽 高 兴 陈英光 　　河北衡水市精神病医院 河北衡水 053800 　　【摘 要】目的：探讨舒肝解郁胶囊治疗广泛性焦虑障碍的疗效及安全性。方法：将60例广泛性焦虑障碍患者随机分为观察组和对照组各30例，观察组给予舒肝解郁胶囊治疗，对照组给予盐酸丁螺环酮治疗，6周为1疗程。于治疗前及治疗6周末采用汉密尔顿焦虑量表(HAMA)评定临床疗效，副反应量表(TESS)评定不良反应。结果：观察组显效率66.7%，有效率为87.0％；对照组：显效率60.0%，有效率为86.7％，两组患者疗效比较无显著性差异( t =1.233，P gt;0.05)。且两组治疗后 HAMA评分均较治疗前有显著下降(P lt;0.01)，治疗前后两组间HAMA评分无显著性差异(P＞0.05)，但两组治疗后副反应观察组小于对照组，TESS评分有显著性差异 (P＜0.05)。结论：舒肝解郁胶囊治疗广泛性焦虑障碍与盐酸丁螺环酮整体疗效相当，不良反应较少，值得临床推广使用。 　　【关键词】舒肝解郁胶囊；盐酸丁螺环酮；不良反应；广泛性焦虑障碍 　　【中图分类号】R277.7 【文献标识码】B 【文章编号】1764-8999（2015）7-0495-01 　　【Abstract】Objective: To investigate the efficacy and safety of Shugan Jieyu capsule in the treatment of generalized anxiety disorder. Methods: 60 patients with generalized anxiety disorder were randomly divided into observation group and control group with 30 cases in each group, the observation group was given Shugan Jieyu capsule treatment, the control group was givenbuspirone hydrochloride treatment, 6 weeks for 1 courses. On the 6 weekend of treatment and the Hamilton Anxiety Scale (HAMA) before treatment and assessment of clinical efficacy, side effects scale (TESS) assessment of adverse reaction. Results: in the observation group was 66.7%,effective rate was 87%; the control group: the effective rate was 60%, effective rate was 86.7%,there was no significant difference between the efficacy of the two groups (t =1.233, P gt;0.05). And the two group the HAMA score after treatment than before treatment was significantly decreased (Plt;0.01), HAMA score before and after treatment between the two groups had no significant difference (P gt; 0.05), but the two groups after treatment, observation of side effects in group than the control group, the scores of TESS were significant difference (P lt; 0.05). Conclusion: Shugan Jieyu capsule rather in treatment of generalized anxiety disorder and buspirone hydrochlorideoverall curative effect, less adverse reaction, it is worthy of clinical use. 　　【key