接头分子Cbl与血管再狭窄的防治PPT.ppt

Fighting Restenosis: Targeting c-Cbl; Coronary artery disease: a significant health threat afflicting millions of individuals worldwide. Despite the development of a variety of technologies and catheter based interventions, post-procedure restenosis is still a significant concern. Gene therapy has emerged as a promising approach aimed at modifying cellular processes that give rise to restenosis. ;Gene Therapy-Preclinical Study ;c-Cbl;Aim of the Study;A Hierarchical Signaling Cascade from c-Cbl to PI3K/akt/mTOR in SMCs;Ablation of c-Cbl Tyrosine Phosphorylation: A Tool to Fight Restenosis?;Conditional Expression of c-Cbl Mutant in SMCs;c-Cbl-m Suppressed SMC Proliferation and Migration ;c-Cbl-m Restricted G1/S Progression in SMCs;c-Cbl-m Inhibited PI3K/Akt/mTOR Activation in SMCs;Constitutive Activation of PI3K or Akt Attenuated the c-Cbl-m Effects ;15;c-Cbl-m Increased Ubiquitination of PDGF and FGF Receptors ;Adenovirus-mediated Gene Transfer of c-Cbl-m Inhibits Akt/mTOR Activation in vivo;c-Cbl-m Inhibits SMC Proliferation and Migration in vivo;c-Cbl-m Inhibits Intimal Hyperplasia in Balloon-injured Arteries;Proposed role of c-Cbl in vascular Remodeling;Acknowledgment