二1pgdh在胃癌中的表达及其与cox-2.docVIP

15-PGDH在食管癌中的表达特征及意义( （中国人民解放军第四军医大学唐都医院消化内科，陕西 西安 710038，中国） 的 探讨15-羟基前列腺素脱氢酶(15-PGDH)在癌中的表达及其与临床病理特征的关系，并初步评价其意义。方法 随机收集例癌手术病人的癌组织及相应癌旁正常组织，应用免疫组织化学检测15-PGDH表达特征并进行评分，进一步分析15-PGDH的表达特征与食管癌临床病理参数关系。结果癌中15-PGDH的表达水平显著降低甚至缺失。临床病理学相关性统计分析，15-PGDH结论癌中15-PGDH的表达减少或缺失参与了食管癌的发生发展过程 关键词；15-羟基前列腺素脱氢酶；R735.2 文献标识码A 文章编号： Expression and clinical significance of 15-hydroxyprostaglandin dehydrogenase in esophagus cancer LIU Zhen-xiong, Qin Ming, Zhao Shu-guang, WANG Xu-xia, WANG jing-jie (Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi’an, 710038, China） ABSTRACT: Objective To investigate the expression and clinical significance of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) protein in esophagus cancer. Methods Immunohistochemistry was used to detect the expression of 15-PGDH protein in 66 esophagus cancer tissues and adjacent non-tumor tissues. Statistic analyses were explored to value its relation with the clinicopathological parameters. Results 15-PGDH expression was found decreased or even absent in esophagus cancer tissues compared with the corresponding non-tumor tissues. Further analysis about its relationship with clinicopathological parameters revealed that the downregulated of 15-PGDH was significantly related with differentiation grade, TNM stage and lymph node metastasis. Conclusions The expression of 15-PGDH is decreased or even absent in esophagus cancer tissues. The results suggest that 15-PGDH may be an important indicator in carcinogenesis and progression of esophagus cancer. Key words: Esophagus cancer; 15-hydroxyprostaglandin dehydrogenase (15-PGDH); Clinical Pathologic Parameters Chinese Library Classification:R735.2 Document code:A 前言 食管癌是最常见的恶性肿瘤之一，严重威胁人类的生命健康近年研究显示，5-羟基前列腺素脱氢酶(15-hydroxyprostaglandin dehydrogenase, 15-PGDH)是在癌、癌、结肠癌等多种肿瘤中低表达，而恢复其表达则能抑制肿瘤的生长及转移，提示15-PGDH可能起着抑癌基因的作用[1,,4,5]。然而，15-PGDH与癌的关系并不。在癌组织中的并分析其表达与癌临床病理特征的关系以探讨15-PGDH在癌发生发展中的作用 1 材料与方法 1.1 材料 1.1.1 组织标本收集20年9月至20年9月第四军医大学唐都医院手术切除的癌