新模板课件-胆碱受体阻断药.pptVIP

Zhi-guo Song ;Cholinoceptor blocking drugs;M-R blocking drugs;曼陀罗;M-R blocking drugs;洋金花;Smooth muscle: relaxes splanchnic smooth muscle Heart: decrease heart rate (blocking M1-R) higher doses: increase heart rate (blocking M2-R) antagonize atrioventricular block and arrhythmia Blood vessel and pressure: dilation Central nervous system: excite depress;Clinical uses;Dry mouth, blurred vison, tachycardia, mydriasis CNS: restlessness, hallucinations depression Poisoning rescue: physostigmine Contraindication:glaucoma, prostatic hypertrophy;Scopolamine (东茛菪碱);synthetic mydriatic Homatropine (后马托品) mydriasis occurs more rapidly and has a shorter duration than atropine synthetic antispasmodic Ipratropium bromide(异丙托溴铵) Bronchial asthma selective M1-R antagonist Pirenzepine (哌仑西平), Telenzepine (替仑西平) Gastric ulcer treatment;N-cholinoceptor blocking drugs ;Mecamylamine (美加明) Trimethaphan (樟磺咪酚) Clinical use: hypertensive crisis Adverse effects: many and severe;Depolarizing neuromuscular blockers succinycholine Nondepolarizing neuromuscular blockers curare;Depolarizing neuromuscular blockers;Succinycholine (琥珀胆碱, scoline) ;Nondepolarizing neuromuscular blockers;Tubocurarine(筒箭毒碱)