缺血对心肌中连结蛋白43和乙酰胆碱M受体亚型M3 (M3-mAChR)结合的影响PPT.pptVIP

Ischemia Impairs the Association Between Connexin 43 and M3 Subtype of Acetylcholine Muscarinic Receptor (M3-mAChR) in Ventricle Myocytes;Introduction;The association between Connexin43 and M3-mAChR in ventricular myocytes. The role of M3-mAChR in cytoprotection of myocardial infarction.; ;A confocal image showing the expression of connexin 43 in myocardium under control conditions and after ischemia.;3. The effects of ischemia on the expression of M-R and connexin 43. ;The effect of ischemia on the expression of connexin 43 in the plasma membrane. ;The effect of ischemia on the association between M2 or M3-mAChR and connexin 43. ;4. The effect of choline pretreatment on the association between M3/M2 mAChR and connexin 43. ;5. Effects of Choline on Hemodynamic Parameters during Coronary Artery Occlusion.;6. Effects of choline on ischemic arrhythmias and the potential role of M3-mAChRs. ;7. Effect of choline on infarct size and the potential role of M3-mAChRs. ;8. Effect of choline on cardiomyocytes apoptosis and the potential role of M3-mAChRs. ;Conclusions;Thanks