新辅助化疗前apollon在乳腺癌组织中的表达及意义.pdfVIP

J South Med Univ, 2015, 35(8): 1201-1205 doi 10.3969/j.issn. 1673-4254.2015.08.24 ·1201 · 临床研究 新辅助化疗前新辅助化疗前apollonapollon 在乳腺癌组织中的表达及意义在乳腺癌组织中的表达及意义 陈建发，岳志强，傅 明，莫 友，周淑蓉 解放军第四二二中心医院普外科，广东 湛江 524009 摘要：目的调查乳腺癌标本中apollon 免疫组化表达是否能够预测新辅助化疗（NAC ）后的病理完全缓解（pCR ）。方法 采用免 疫组化技术检测124例乳腺癌患者活检组织内的apollon、Her-2、ER（雌激素受体）及PR（孕激素受体）表达。通过实体肿瘤反应 评价标准（RECIST）评价NAC 疗效。分析不同型乳腺癌的pCR 率。分析apollon状态与Her-2 状态、ER 状态、PR 状态、淋巴结状 态及肿瘤大小之间的相关性。采用免疫组化技术比较了NAC 前后乳腺癌切片内apollon 的表达变化。结果 pCR 率为18.5% （23/ 124）并与apollon、ER 及PR 表达关系密切：apollon 阴性apollon 阳性、ER 阴性ER 阳性及PR 阴性PR 阳性。Apollon 与 Her-2 状态、ER 状态、PR 状态及淋巴结状态相关。另外，化疗显著下调了肿瘤细胞内apollon 的表达。结论 Apollon 阴性表达可 能是pCR 的一个预测因子。 关键词：apollon ；免疫组化表达；乳腺癌；病理完全缓解；新辅助化疗；活检 Immunoexpression of apollon in breast cancer tissues before neoadjuvant chemotherapy and its clinical significance CHEN Jianfa, YUE Zhiqiang, FU Ming, MO You, ZHOU Shurong Department of General Surgery, 422 Hospital of PLA, Zhanjiang 524009, China Abstract: Objective To investigate whether apollon immunoexpression in breast cancer tissues helps to predict pathological complete response (pCR) after neoadjuvant chemotherapy (NAC). Methods The expressions of Apollon, Her-2, estrogen receptor (ER) and progesterone receptor (PR) were detected immunohistochemically in biopsy tissues from 124 breast cancer patients. The clinical responses to NAC were evaluated in line with the response evaluation criteria in solid tumors (RECIST). The pCR rate was analyzed for different types of breast cancer. The correlations between Apollon status with Her-2, ER, PR, lymph node status and tumor size were analyzed. Immunohistochemistry was used to compared the changes in Apollon expression in the breast cancer tissues before and after NAC. Results The pCR rate was 18.5% (23/124) in these patients. Negative expressions of apollon, ER and PR were all associated with a