辛伐他汀对CHD患者氧化应激的影响.docVIP

精品论文 参考文献 辛伐他汀对CHD患者氧化应激的影响 施盛霞 　　(南京市江宁区百家湖社区卫生服务中心 211102) 　　【摘要】目的 探讨了辛伐他汀对CHD患者氧化应激作用对血脂的影响，观察了辛伐他汀及安慰剂对66例CHD患者血清丙二醛（MDA）、超氧化物歧化酶（SOD）和血脂的影响。方法 应用生化法分别测定CHD患者MDA、SOD、TG、TC、LDL-C和VLDL-C水平，并与安慰剂服用者进行比较。结果 CHD患者在治疗前血清SOD水平降低、MDA水平升高。经辛伐他汀治疗3个月后，患者SOD水平上升，MDA水平明显下降（plt;0.05）。安慰剂处理前后血清SOD及MDA水平无显著性差异（pgt;0.05）。辛伐他汀治疗组TG、TC、LDL-C和VLDL-C较治疗前下降，而HDL水平与治疗前相比上升（plt;0.05），安慰剂处理前后患者血脂谱无显著性差异（pgt;0.05）。结论 辛伐他汀对CHD患者氧化应激有明显的抑制作用，且有益于血脂的调节。 　　【关键词】 冠心病 辛伐他汀 氧化应激 血脂 　　【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752（2014）14-0105-02 　　Inhibitory effects of simvastatin on oxidative stress in patients with Coronary heart diseases (CHD) 　　BAIJIAHU COMMUNITY HEALTH CENTRE Jiangning Nanjing Shi Shengxia 　　【Abstract】Objective: To explore the effects of simvastatin on oxidative stress and blood lipid metabolism in patients with CHD. Methods: serum SOD、MDA、TG、TC、LDL-C and VLDL-C(with Biochemistry) levels were wheasured in 66 patients with CHD and 36 controls. Results: serum levels of SOD in CHD before treatment were significantly lower, and levels of MDA was higher than those in controls (plt;0.05). The serum levels of SOD in patients after 3 months consecutive simvastatin treatment were significantly higher and whereas the serum level of MDA was significantly lower than those of before the treatment (pgt;0.05). There was no significant difference on the serum levels of SOD and MDA observed before and after treatment in the placebo group (plt;0.05). The serum levels of HDL-C in patients after treatment with simvastatin were higher and while the serum levels of TG, TC, LDL-C and VLDL-C were significantly lower than those of before the treatment (pgt;0.05). There was no significant difference on the profiles of lipid before and after treatment in the placebo groups . Conclusions: simvastatin could significantly inhibit oxidative stress provoked by hyperglycemia and had beneficial effects on the lipid homeostasis in patients with C