酪酸梭菌三联活菌片辅助三联疗法清除幽门螺杆菌的疗效探析.docVIP

精品论文 参考文献 酪酸梭菌三联活菌片辅助三联疗法清除幽门螺杆菌的疗效探析 马鹏飞 　　（安徽省儿童医院 安徽 合肥 230000） 　　【摘要】 目的：对酪酸梭菌三联活菌片联合三联疗法清除幽门螺杆菌（Helicobacter pylori,Hp）的效果分析。方法：对我院收治的120例患幽门螺杆菌患者随机分为不同治疗方案组：治疗组（以下简称A组）、对照组（以下简称B组），疗程均为2周。疗程结束后停药4周行尿素【13C】呼气试验，并分析评估其各自的疗效。结果：两组按意向性分析（ITT），A、B组对幽门螺杆菌的清除率分别为81.7%、63.3%；两组按符合方案集分析（PP），A、B组对幽门螺杆菌的清除率分别为84.5%、64.4%，A组对幽门螺杆菌的清除率显著高于B组，两组比较具有统计学意义（Plt;0.05）；不良反应发生率A组为15%、 B组为30%，A组不良反应明显低于B组，其差异具有统计学意义。组内比较在慢性胃炎、胃溃疡患者幽门螺杆菌清除率方面没有统计学意义。结论：酪酸梭菌三联活菌片联合三联疗法对幽门螺杆菌的清除率明显高于传统三联疗法，且不良反应率低，值得推广应用。 　　【关键词】 酪酸梭菌三联活菌片；幽门螺杆菌；清除率；不良反应 　　【中图分类号】R37 【文献标识码】A 【文章编号】2095-1752（2016）18-0070-02 　　Sanlian curative effect analysis of butyric acid bacteria living bacterium of auxiliary triple therapy removal of helicobacter pylori 　　Ma Pengfei . Childrens Hospital in Anhui Province, Anhui Province, Hefei 230000, China 　　【Abstract】Objective Sanlian living bacterium of butyric acid bacteria tablets combined triple therapy removal of Helicobacter pylori (Helicobacter pylori, Hp) analysis of the effect. Methods To our hospital 120 cases of patients with helicobacter pylori were randomly divided into treatment group (group A) and control group (group B), A course of 2 weeks. Results Clearance for helicobacter pylori, group A was significantly higher than that of group B, the results statistically significant (P lt; 0.05); Incidence of adverse reaction of group A was 15%, B group was 30%, the adverse reaction of group A was lower than that in group B, the difference is statistically significant. Conclusions Sanlian butyric acid bacteria living bacterium piece of joint clearance of triple therapy for helicobacter pylori was obviously higher than that of traditional triple therapy, and low rate of adverse reactions, is worthy of popularization and application. 　　【Key words】Sanlian butyric acid bacteria living bacterium; Helicobacter pylori; Clearance; Adverse reactions 　　澳大利亚科学家巴里?马歇尔和罗宾沃伦，联合取自100个病人的活组织切片进行研究。经过反复试验，马歇尔成功地培育出一种后来被命名为幽门螺杆菌的细菌[1]，为了表彰他们发