不同麻醉方法对妇科手术患者免疫功能的影响.docVIP

不同麻醉方法对妇科手术患者免疫功能的影响 　　[摘要] 目的 ?^察并分析不同麻醉方法对妇科手术患者免疫功能的影响。 方法 选取2014年1月～2015年12月在十堰市妇幼保健院进行妇科手术的患者156例为研究对象，根据麻醉方式将所有患者分为三组，A组采用右美托咪定静脉泵注联合七氟烷吸入麻醉，B组采用七氟烷吸入麻醉，C组采用丙泊酚联合舒芬太尼麻醉。观察所有患者麻醉开始前（T0）、术后2 h（T1）、术后6 h（T2）、术后12 h（T3）、术后1 d（T4）、术后3 d（T5）、术后7 d（T6）时的收缩压（SBP）、舒张压（DBP）、心率（HR）、呼吸率（RR）和血氧饱和度（SpO2）外周血T淋巴细胞亚群数量变化情况及炎症细胞因子变化。 结果 A组患者T1、T2、T3时的SBP，T1、T2时的DBP、RR，T1、T6的TNF-α水平，T1～T6的IL-6、IL-8水平，T1时的CD3+水平，T1、T2时的CD4+水平与T0时比较，差异有统计学意义（P 　　[关键词] 免疫功能；妇科手术；麻醉；影响 　　[中图分类号] R314 [文献标识码] A [文章编号] 1673-7210（2017）06（a）-0059-04 　　Effects of different anesthesia methods on immune function in patients with gynecological surgery 　　CHEN Xinyan WANG Lei NIU Shikun FANG Xianjie 　　Department of Anesthesiology， Shiyan Maternal and Child Health-Care Hospital， Hubei Province， Shiyan 442000，China 　　[Abstract] Objective To observe and analyze the effects of different anesthesia methods on immune function in patients with gynecological surgery. Methods From February 2014 to December 2015， in Shiyan Maternal and Child Health-Care Hospital， 156 patients underwent gynecological surgery were selected， they were divided into three groups by the anesthesia method， group A was given Dexmedetomidine intravenous infusion combined with Sevoflurane inhalation anesthesia， group B was given Sevoflurane inhalation anesthesia， group C was given Propofol combined with Sufentanil anesthesia. The changes of SBP， DBP， HR， RR， SpO2， peripheral blood T lymphocyte subsets and inflammatory cytokines of all patients were observed at before anesthesia （T0）， after surgrey 2 h （T1），after surgrey 6 h （T2）， after surgrey 12 h （T3）， after surgrey 1 d （T4）， after surgrey 3 d （T5）， after surgrey 7 h （T6）. Results The levels of SBP at T1， T2， T3， DBP， RR at T1， T2， TNF-α at T1， T6， IL-6， IL-8 at T1-T6， CD3+ at T1， CD4+ at T1， T2 of group A were compared with those at T0， the differences were statistically significant （P 　　[Key words] Immune function； Gynecological surgery； Anesthesia； Influences 　　宫腔镜电切术在临床治疗方面具有手术创