钙通道阻滞剂对高血压牙龈增生患者的影响因素分析.docVIP

精品论文 参考文献 钙通道阻滞剂对高血压牙龈增生患者的影响因素分析 南通市第四人民医院口腔科 江苏南通 226005 【摘 要】目的：探讨服用钙通道阻滞剂(CCB)后的高血压患者出现牙龈增生的患病率。方法：对我院体检中心和心血管内科门诊服用钙通道阻滞剂抗高血压类药物的262和未服用钙通道阻滞剂的197例患者进行横断面调查。包括问卷调查和口腔牙周检查。结果：服用钙通道阻滞剂类药物患者的牙龈增生患病率为20.23%，显著高于对照组的2.54%(chi;2=32.276，Plt;0.05)。随年龄增大，药物性牙龈增生的患病率降低(r=-0.155，Plt;0.05)；单一用药者较联合用药者患病率高；服药时间越长患病率降低；随服药剂量的增加，患病率明显增长；口腔卫生状况差者可加重牙龈增生程度。结论：药物性牙龈增生是多方面作用的结果，其主要影响因素为患者年龄、服药方式、剂量、时间和牙周局部因素。 【关键词】牙龈增生；钙通道阻滞剂；危险因素 Influence factors analysis of calcium channel blockers in high blood pressure with gingival hyperplasia patients Liu Wenxue The fourth peoples hospital dental of NanTong city JiangSu 226005 [Abstract] objective：To explore the prevalence of taking calcium channel blockers (CCB) patients with high blood pressure after gingival hyperplasia.Methods：Physical examination center taking calcium channel blockers and cardiovascular internal medicine clinic of antihypertensive drugs in 262 and is not taking calcium channel blockers cross-sectional survey of 197 patients.Including the questionnaire and oral and periodontal examination.Results：The patients treated with calcium channel blockers drugs gingival hyperplasia prevalence was 20.23%，significantly higher than that of control group 2.54% (chi-square=32.276，Plt; 0.05).Along with the age increasing，the prevalence of drug-induced gingival hyperplasia lower (r = 0.155，P lt; 0.05)；Single people more joint high prealence of people；Taking the longer prevalence rates；With the increase of the dose，the prevalence of significant growth；Oral health status memory can aggravate degree of gingival hyperplasia.Conclusion：drug-induced gingival hyperplasia is the result of a multifaceted role，the main influence factors for patients with age，medication，dosage，time and periodontal local factors. [key words] GLingival hyperplasia；Calcium channel blockers；Risk factors 引起牙龈增生的钙通道阻滞剂中，硝苯地平引起牙龈增生的发病率为6.3%-83%[1]。CCB类是治疗心血管系统疾病的常用药，且临床疗效好，患者往往换药或停药后不能达到理想的降压效果。本研究通过对相关人群的横向调查，观察相关危险因素对