血管内皮生长因子在肿瘤血管形成中的作用及其靶向治疗研究进展.pdfVIP

146 Aug 2015, Vol. 3, No.3 · · 中华临床实验室管理电子杂志2015 年8 月第3 卷第3 期　Chin J Clin Lab Mgt (Electronic Edition), • 综述• 血管内皮生长因子在肿瘤血管形成中的 作用及其靶向治疗研究进展 王鲁　常艳丽　张青云 【摘要】　肿瘤发展依赖于组织周围新生血管的形成。在众多促进血管生成的内源性因子中，血 管内皮生长因子(vascular endothelial growth factor，VEGF)发挥了关键性作用，因此，以VEGF为靶点 进行抗肿瘤血管生成成为抗癌治疗的重要策略。截至目前，大量靶向VEGF信号转导系统的抗血管生 成药物已应用于临床或处于临床试验阶段，包括VEGF单克隆抗体、VEGF受体激酶抑制剂及作用于 其下游信号通路的小分子抑制剂等。本文针对VEGF 的信号转导系统及其靶向治疗现状予以综述，并 简要阐述抗肿瘤血管生成治疗过程中耐药现象的产生机制。 【关键词】　血管内皮生长因子；　抗血管生成治疗；　靶向治疗；　肿瘤耐药 Roles of vascular endothelial growth factor in the angiopoiesis and its targeted therapy　Wang Lu, Chang Yanli, Zhang Qingyun. Department of Clinical Laboratory, Key Laboratory of Carcinogenesis and Translational Research Ministry of Education, Peking University Cancer Hospital Institute, Beijing 100142, China Corresponding author: Zhang Qingyun, Email: zhqy_208@163.com 【Abstract 】　Progression of tumor depends on angiogenesis in a malignant tissue. Among the numerous endogenous promoters of angiogenesis, vascular endothelial growth factor(VEGF) plays a leading role. VEGF targeted angiogenesis therapy has the remarkable anticancer strategy. So far, there have been many antiangiogenic agents applied in clinic or in clinic trials, including anti VEGF monoclonal antibodies, VEGF receptor kinase inhibitors and small molecular inhibitors targeting on the downstream signal pathways. This review will interpret the VEGF signal system and the status of its targeted treatment. In addition, the mechanism of tumor resistance to antiangiogenic therapy will bee laborated briefly. 【Key words 】　Vascular endothelial growth factor;　Antiangiogenic therapy;　Target therapy;　 Tumor resistance 血管生成可为肿瘤组织提供充足的营养和氧 性靶向结合血管内皮生长因子(vascular endothelial 气，并带走其代谢产生的废物及CO ，是肿瘤生 growth