导向基促进的金属催化酰胺衍生物碳氢键烷基化的-中国科技论文在线.PDF

中国科技论文在线 导向基促进的金属催化酰胺衍生物碳氢键 烷基化的研究 王达典，谭泽** 5 410000 摘要： 8- 10 4 2 0.5 2ml 1 8- 12 8- 关键词： 15 中图分类号：O626 Metal catalyzed C-H bond alkylation with the aid of directing group WANG Dadian, TAN Ze 20 (College of Chemistry and Chemical Engineering, Hunan University, Changsha 410000) Abstract: Directly alkylation of C-H bonds has always been an important part of C-H activation, and it is also significant to organic synthesis. In this paper, Cu catalyzed ortho-C-H bond alkylation of benzamide derivatives with 8-aminoquinoline directing groups by making use of methyl radical, which is generated by DTBP is achieved.To obtain an optimized yield, benzamide derivatives are reacted with 25 DTBP while a variety copper salt, ligant, base, solvent and temperature are used. The best reaction condition was conformed as follow: 0.3 mmol N-(quinolin-8-yl)benzamide react with DTBP(2 equiv), potassium phosphate(4 equiv) , Copper acetate (0.5 equiv) , in cyclohexane at 130 ℃.The scope of this reaction was also extanded. Key words: organic chemistry, Copper catalyst, directing groups, C-H activation, alkylation reaction 30 0 引言 在有机合成中，碳碳键的构建一直都是十分重要的领域，而通过过渡金属催化则是构 建碳-碳的重要方法