Reactive Oxygen Species in the Vasculature Molecular and英文资料.pdfVIP

Reactive Oxygen Species in the Vasculature Molecular and Cellular Mechanisms Yoshihiro Taniyama, Kathy K. Griendling Abstract—Accumulating evidence indicates that reactive oxygen species (ROS) play major roles in the initiation and progression of cardiovascular dysfunction associated with diseases such as hyperlipidemia, diabetes mellitus, hypertension, ischemic heart disease, and chronic heart failure. ROS produced by migrating inflammatory cells as well as vascular cells (endothelial cells, vascular smooth muscle cells, and adventitial fibroblasts) have distinct functional effects on each cell type. These include cell growth, apoptosis, migration, inflammatory gene expression, and matrix regulation. ROS, by regulating vascular cell function, can play a central role in normal vascular physiology, and can contribute substantially to the development of vascular disease. (Hypertension. 2003;42:1075-1081.) Key Words: antioxidants vascular disease muscle, smooth, vascular endothelium free radicals macrophages oxidative stress ccumulating evidence indicates that oxidative stress Enzymatic Superoxide Production Aplays a major role in the initiation and progression of Multiple enzymatic systems produce O2 · and its derivatives cardiovascular dysfunction associated with diseases such as in the vasculature, including NAD(P)H oxidases, XO, nitric hyperlipidemia, diabetes mellitus, hypertension, ischemic oxide synthases (NOS), and MPO. The relative importance of heart disease, and chronic heart failure. Oxidative stress is a each of these proteins appears to vary with the physiologic