Renal cell apoptosis induced by nephrotoxic drugs cellular英文资料.pdfVIP

Apoptosis (2008) 13:11–32 DOI 10.1007/s10495-007-0151-z ORIGINAL PAPER Renal cell apoptosis induced by nephrotoxic drugs: cellular and molecular mechanisms and potential approaches to modulation H. Servais Æ A. Ortiz Æ O. Devuyst Æ S. Denamur Æ P. M. Tulkens Æ M.-P. Mingeot-Leclercq Published online: 30 October 2007 Springer Science+Business Media, LLC 2007 Abstract Apoptosis plays a central role not only in the ined. Finally, key issues that need to be addressed for the physiological processes of kidney growth and remodeling, success of apoptosis-based therapies are underlined. but also in various human renal diseases and drug-induced nephrotoxicity. We present in a synthetic fashion the main Keywords Renal apoptosis Nephrotoxic drugs molecular and cellular pathways leading to drug-induced apoptosis in kidney and the mechanisms regulating it. We Abbreviations illustrate them using three main nephrotoxic drugs (cis- AIF Apoptosis induced factor platin, gentamicin, and cyclosporine A). We discuss the Akt/PKB Serine/threonine kinase/protein kinase B main regulators and effectors that have emerged as key ATP Adenosine triphosphate targets for the design of therapeutic strategies. Novel Bid Bcl-2 interacting domain approaches using gene therapy, antisense strategies, BIP Bax inhibiting peptide recombinant proteins, or compounds obtained from both