孔健教授-Reaearch Design6.pdf

It takes a village to perform an acupuncture fMRI study Jian Kong Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA It Takes a Village  acupuncture  MRI physics  fMRI data analysis  Neuroscience Aim of the study Find the right question to ask ! Pros and Cons of imaging tools Understanding acupuncture – historic and development - Story of san yi jiao and stomach meridian Story of Vision point and hearing point Cho et al PNAS, 1998 Comparison of direct visual stimulation of the eye and acupuncture stimulation of vision-related acupoint VA1 for all 12 subjects. Red overlays correspond with responses from acupuncture stimulation having a positive correlation with signal intensity, i.e., ‗‗yin‘‘ character. Blue overlays correspond to responses with Cho et al PNAS, 1998 Results from other studies Other studies ―claim‖ supporting Cho‘s findings Lee H, Am J Chin Med 2002. Siedentopf C, Neurosci. Lett. 2002. Li et al Neuroreport 2003. Litscher, et al. Lasers Med Sci. 2004. Parrish, et al. IEEE Eng Med Biol Mag 2005. … Other studies that do NOT support Cho Gareus et al J Magn Reson Imaging. 2002 Hu et al Zhong Gong Zhen Jiu (Chinese Acu.) 2005 … (Neuroimage, 2007) Interval Between Scan Sessions 20-30min 3-6 days Session 1 Session 2 Session 3 1-3 weeks 1-3 weeks 1-3 weeks Session 4 Session 5 Session