药理学--镇痛药ppt课件.ppt

* LOGO 镇痛药Analgesics Teacher: Du Can Instructor: jinlong , Huang Opioid alkaloids narcotic analgesics Synthetic pain relievers others Antipyretic anti-inflammatory analgesic analgesics Papaver somniferum（罂粟） Poppies(罂粟花) Poppy fruit (罂粟果) opium Morphine refining from the opium, Bitter,white,needle,crystallization powder Opioid receptor pain pathways limbic system CNS locus coeruleus nuclear midbrain cover former nuclear solitary nucleus the digestive canal smooth muscle Pharmacological effects 1. Central Nervous System （1）analgesia and sedative （2）respiratory depression （3）depressed cough （4）other actions 2.Peripheral System （1）gastrointestinal effects ① diastolic gastrointestinal smooth muscle ② inhibit the secretion of digestive ③ inhibit CNS （2）cardiovascular system ① dilate blood vessels ② increases intracranial pressure. Constipation（便秘） 3. Immune System （1） immunosuppression Clinnical uses 1.analgesia (1)acute sharp pain (2)biliary and kidney colic etc., combined with atropine 2.acute pulmonary edema (1)vasodilation (2)sedative (3)inhibiting respiration 3 severe diarrhea Adverse effects 1.common side effects (1)nausea, vomiting, constipation, (2)respiratory depression, (3)hypotension, 2.tolerance and physical dependence Contraindication 1.women in delivery and lactation. 2.patients with bronchial asthma and pulmonary heart disease. 3.patients with cranial injury and high cranial pressure. 1、《药理学》教材 杨宝峰 苏定冯主编 人民卫生出版社2013年出版 2、《药理学》教材 颜光美主编 高等教育出版社 2009年出版 3、《病理生理学》英文版教材 王建枝 陈国强主编 科学出版社 2007年出版 ? References Review Questions 1.What is the morphine pharmacological effects ?? 2.What is the morph