抗生素PPT课件（英文精品） Surviving SepsisPPT.ppt

Surviving Sepsis; The SEPSIS CASCADE;The Sepsis Continuum;Sepsis: A Major Cause of ICU Death;Surviving Sepsis Campaign;Key Components;Key Components: Prevent Complications of Critical Illness;Key Components: Infection Control;Early Appropriate Antibiotics and Source Control;Therapy Across the Sepsis Continuum;Therapy Across the Sepsis Continuum ;Goal Directed Therapy;Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. NEJM 2001;345:1368.;Patient randomized N=263;CVP: central venous pressure MAP: mean arterial pressure ScvO2: central venous oxygen saturation;;Fluid Resuscitation;SAFE Study;The SAFE Study Investigators, N Engl J Med 2004;350:2247-2256;SAFE STUDY;The SAFE Study Investigators, N Engl J Med 2004;350:2247-2256;What Pressors for Septic Shock ?;Norepinephrine vs Dopamine+/_ Epinephrine in Septic Shock;;Why Vasopressin ?;; A. Normal B. After one hour of hemorrhagic shock;Why Vasopressin ?;Therapy Across the Sepsis Continuum ;Glucose Control: Mechanisms;Tight Glucose Control;Randomization;Tight Glucose Control Improved Survival ;ICU Mortality was reduced by 42%;Tight Glucose Control;Van den Berghe, G. et al. N Engl J Med 2006;354:449-461;Van den Berghe, G. et al. N Engl J Med 2006;354:449-461;Sepsis;Activated Protein C in Sepsis;PROWESS Study Design ;p=0.0054;Adverse Events with Drotrecogin alfa;Mortality as a Function of APACHE II at Study Entry;Xigris (Drotrecogin);Sepsis;Adrenal Insufficiency in Septic Shock;Stress Dose Corticosteroids in Sepsis;Low Dose Steroid Treatment in Septic Shock: Study Design;;Low Dose Steroid Treatment in Septic Shock:28 Day Mortality (Non-responders vs. Responders);Corticosteroids in Sepsis;SURVIVING SEPSIS;SURVIVING SEPSIS;PREVENT COMPLICATIONS;Acknowledgement