PD-1 mRNA expression is associated with clinical and viral profile and PD1 3′-untranslated region polymorphism in patients with chronic HBV infection.pdfVIP

Immunology Letters 162 (2014) 212–216 Contents lists available at ScienceDirect Immunology Letters j o u r n a l h o me p a ge : w w w. elsev /locate/immlet PD-1 mRNA expression is associated with clinical and viral profile and PD1 3 -untranslated region polymorphism in patients with chronic HBV infection Guoyu Zhang a , Na Li a , Pingping Zhang a , Fang Li a , Cuiling Yang a , Qianqian Zhu a , Qunying Han a , Yi Lv b,c , Zhihua Zhou a , Zhengwen Liu a,c,∗ a Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’ an, 710061, Shaanxi, China b Department of Hepatobiliary Surgery, First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, 710061, Shaanxi, China c Institute of Advanced Surgical Technology and Engineering, Xi’an Jiaotong University, Xi’ an, 710061, Shaanxi, China a r t i c l e i n f o a b s t r a c t Article history: Programmed cell death-1 (PD-1) is involved in hepatitis B virus (HBV) infection and single-nucleotide Received 2 May 2014 polymorphism (SNP) r in the 3 -untranslated region (3 UTR) of PD1 gene was shown to Received in revised form 7 August 2014 be associated with the disease course of HBV infection. This study examined the associations of PD-1 Accepted 1 September 2014 mRNA expression with the clinical and viral profiles and the genotypes of r in HBV infec- Available online 9 Septemb