Precision medicine in age-specific non-small-cell-lung-cancer patients_ Integrating biomolecular results into clinical practice—A new approach to improve personalized translational research.pdfVIP

Lung Cancer 107 (2017) 84–90 Contents lists available at ScienceDirect Lung Cancer j o u r n a l h o m e p a g e : w w w. elsev /locate/lung can Precision medicine in age-specific non-small-cell-lung-cancer patients: Integrating biomolecular results into clinical practice—A new approach to improve personalized translational research Tiziana Vavalà, Valentina Monica 1, Marco Lo Iacono, Teresa Mele, Simone Busso, Luisella Righi, Mauro Papotti, Giorgio Vittorio Scagliotti, Silvia Novello ∗ Department of Oncology, University of Turin AOU San Luigi, Regione Gonzole 10, 10043 Orbassano (TO), Italy a r t i c l e i n f o a b s t r a c t Article history: Objectives: Non-small-cell-lung-cancer (NSCLC) in young adults (≤45 years-old) accounts for a very small Received 1 March 2016 proportion, as this disease usually occurs in people at older age. The youthful NSCLC may constitute an Received in revised form 11 May 2016 entity with different clinical-pathologic characteristics, having predominance of adenocarcinoma his- Accepted 29 May 2016 tology and affecting mostly non-smoker subjects. However, without specific guidelines, it is currently considered, both clinically and biologically, as the same disease of the older counterpart, although dif- Keywords: ferences have been documented. Youthful NSCLC Materials and methods: Using formalin-fixed paraffin embedded diagnostic tissues (FFPE), targeted Youngs Young patients