Bacterial nucleoid associated proteins, nucleoid structure and gene expression英文文献.pdfVIP

R E V I E W S Bacterial nucleoid-associated proteins, nucleoid structure and gene expression Shane C. Dillon and Charles J. Dorman Abstract | Emerging models of the bacterial nucleoid show that nucleoid-associated proteins (NAPs) and transcription contribute in combination to the dynamic nature of nucleoid structure. NAPs and other DNA-binding proteins that display gene-silencing and anti-silencing activities are emerging as key antagonistic regulators of nucleoid structure. Furthermore, it is becoming clear that the boundary between NAPs and conventional transcriptional regulators is quite blurred and that NAPs facilitate the evolution of novel gene regulatory circuits. Here, NAP biology is considered from the standpoints of both gene regulation and nucleoid structure. Stable RNA genes Despite differences in the cellular organization of a positive or negative manner. An appreciation of the Genes that code for ribosomal Eukarya, Bacteria and Archaea, it is important to remem- higher-order superstructures that link gene expression RNA (rRNA) and tRNA. ber that all three domains rely on DNA to store and rep- and the architecture of the bacterial genome requires Compared with mRNA, rRNA licate genetic information. In each domain the genetic an understanding of the basic organization of the and tRNA are chemically very material has to be organized for storage in