The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a b catenin dependent pathway英文文献.pdfVIP

A rt i c l e s The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a b-catenin- dependent pathway 1,2 1,2 1 1 1 1 1 Pengyuan Yang , Huazhang An , Xingguang Liu , Mingyue Wen , Yuanyuan Zheng , Yaocheng Rui Xuetao Cao . d Intracellular nucleic acid sensors detect microbial RNA and DNA and trigger the production of type I interferon. However, the e v cytosolic nucleic acid–sensing system remains to be fully identified. Here we show that the cytosolic nucleic acid–binding r e protein LRRFIP1 contributed to the production of interferon-b (IFN-b) induced by vesicular stomatitis virus (VSV) and Listeria s e monocytogenes in macrophages. LRRFIP1 bound exogenous nucleic acids and increased the expression of IFN- b induced by r s both double-stranded RNA and double-stranded DNA. LRRFIP1 interacted with b-catenin and promoted the activation of t h g b-catenin, which increased IFN-b expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting i r l the acetyltransferase p300 to the IFN-b enhanceosome via IRF3. Therefore, LRRFIP1 and its downstream partner b-catenin l A constitute another coactivator pathway for IRF3-mediated production of type I interferon. . c n I Type I interferons can be induced by many kinds of viruses and non- Cytosolic double-stranded DNA (dsDNA) is also a potent , a viral pathogens and are important in innate immune responses for activator of innate immune responses in mammalian cells. Cytosolic c i