原创力文档In vivo imaging using bioluminescence a tool for probing graft versus host disease英文文献.pdfVIP
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P E R S P E C T I V E S
known as GVHD2,3. Severe GVHD limits the
I N N OVAT I O N
overall effectiveness of HCT and precludes
the application of this life-saving therapy to
In vivo imaging using other clinical settings, such as for the treat-
ment of severe autoimmune disorders4 or for
bioluminescence: a tool for the induction of tolerance to organ transplan-
tation. The risks of GVHD are substantial,
probing graft-versus-host disease such that 20–60% of patients will develop
this complication following allogeneic HCT,
depending on disease-related factors, such as
Robert S. Negrin and Christopher H. Contag the stage of disease, the age of the recipient
and the degree of genetic disparity between
Abstract | Immunological reactions have a key role in health and disease and are the donor and recipient. The reasons why
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