原创力文档Chromatin Modifications by Methylation and Ubiquitination Implications in the Regulation of Gene Expression英文文献.pdfVIP
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Chromatin Modifications by
Methylation and
Ubiquitination: Implications
in the Regulation of Gene
Expression
Ali Shilatifard
Saint Louis University School of Medicine and the Saint Louis University Cancer
Center, St. Louis, Missouri 63104; email: shilatia@
Annu. Rev. Biochem. Key Words
2006. 75:243–69
First published online as a histone methylation, histone ubiquitination, epigenetic regulation,
Review in Advance on MLL, transcriptional elongation
February 22, 2006
Abstract
The Annual Review of
Biochemistry is online at It is more evident now than ever that nucleosomes can transmit
epigenetic information from one cell generation to the next. It has
doi: 10.1146/ been demonstrated during the past decade that the posttranslational
annurev.biochem.75.103004.142422
modifications of histone proteins within the chromosome impact
c
Copyright 2006 by chromatin structure, gene transcription, and epigenetic informa-
Annual Reviews. All rights
reserved tion. Multiple modifications decorate each histone tail within the
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