Concise Review Nanoparticles and Cellular Carriers Allies in Cancer Imaging and Cellular Gene Therapy英文文献.pdfVIP

TRANSLATIONAL AND CLINICAL RESEARCH Concise Review: Nanoparticles and Cellular Carriers-Allies in Cancer Imaging and Cellular Gene Therapy? CATHERINE TANG,a,b PAMELA J. RUSSELL,a,b ROSETTA MARTINIELLO-WILKS,c,d JOHN E. J. RASKO,c,d APARAJITA KHATRIa,b aOncology Research Centre, Prince of Wales Hospital, Randwick, Sydney, NSW, Australia; bFaculty of Medicine, University of New South Wales, Kensington, NSW, Australia; cGene and Stem Cell Therapy Program, Centenary Institute, University of Sydney, NSW, Australia; dCell and Molecular Therapies, Royal Prince Alfred Hospital, NSW, Australia Key Words. Stem cell tracking and imaging • Magnetic nanoparticles • Mesenchymal stem cells • Cancer • Nanotechnology • Gene therapy • SPION ABSTRACT Ineffective treatment and poor patient management con- safety, vector, and/or transgene immunogenicity as well as tinue to plague the arena of clinical oncology. The crucial nanoparticle clearance and toxicity. The versatility of the issues include inadequate treatment efficacy due to ineffec- nanotechnology platform could allow cellular tracking tive targeting of cancer deposits, systemic toxicities, subop- using single or multimodal imaging modalities. Toward timal cancer detection and disease monitoring. This has that end, noninvasive magnetic resonance imaging (MRI) led to the quest for clinically relevant, innovative multifac- is fast becoming a clinical favorite, though there is scope eted solutions such as development of targeted and trace- for improvement in its accuracy and sensitivity. In able therapies. Mesenchymal stem cells (MSCs) have the that, use of superparamagnetic iron-oxide nanoparticles intrinsic ability to ‘‘home’’ to growing tumors and are (SPION