Dynamic chemical shift imaging for image guided thermal therapy Analysis of feasibility and potential英文文献.pdfVIP

Dynamic chemical shift imaging for image-guided thermal therapy: Analysis of feasibility and potential Brian A. Taylor Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 Ken-Pin Hwang Global Applied Science Laboratory, GE Healthcare Technologies, Waukesha, Wisconsin 53188 and Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 Andrew M. Elliott, Anil Shetty, John D. Hazle, and R. Jason Stafforda Department of Imaging Physics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 Received 7 July 2007; revised 12 December 2007; accepted for publication 12 December 2007; published 30 January 2008 A fast chemical shift imaging CSI technique based on a multiple gradient-recalled acquisition using a small number of echoes with intentional aliasing of the reference lipid peak is studied to determine its feasibility for temperature monitoring. Simulations were implemented to find param- eters where the lipid and water peaks can be measured using a Fourier-based peak fitting approach as well as using an innovative autoregressive moving average technique. A phantom consisting of 50% mayonnaise/50% lemon juice was calibrated to temperature and compared to literature values. A porcine kidney was treated ex vivo with an external laser and imaged with the CSI technique with comparisons to temperature readings from a fluoroptic monitoring system and complex phase difference CPD calculations. To demonstrate the technique in vivo, a Balb/c mouse with a CT26 xenograft in the subcutaneous lower back was treated using gold-coated, silica-core nanoshells heated with an 8