Decision checkpoints in the thymus英文文献.pdfVIP

r e v i e w d e c i s i o n m a k i n g i n t h e i m m u n e s y s t e m Decision checkpoints in the thymus Andrea C Carpenter Rémy Bosselut The development of T cells in the thymus involves several differentiation and proliferation events, during which hematopoietic precursors give rise to T cells ready to respond to antigen stimulation and undergo effector differentiation. This review addresses signaling and transcriptional checkpoints that control the intrathymic journey of T cell precursors. We focus on the divergence of  and  lineage cells and the elaboration of the  T cell repertoire, with special emphasis on the emergence of . d transcriptional programs that direct lineage decisions. e v r e 7 s The T cell arm of the immune system is essential for responses against normally restrains their myeloid development . Thymic colonization e infections. Several T cell subsets are distinguished, on the basis of the involves the chemokine receptor CCR9, probably redundantly with r s composition of their T cell antigen receptor (TCR) (αβ or γδ), their CCR7, and PSGL1, a ligand for P-selectin expressed on the thymic t h g antigenic specificity and their effector potential. αβ T cells consti- epithelium4,8. The loss of multipotency that defines T commitment i r l tute the bulk of T cell populations in lymphoid organs and generally is a gradual process. It occurs in double negative (DN) thymocytes, l A react to peptides presented by either MHC class I or MHC class II which do not express CD4 or CD8—a subset that is itself separated . molecules, whereas γδ T cells are generally n