Impacts of amino acid nutrition on pregnancy outcome in pigs Mechanisms and implications for swine production英文文献.pdfVIP

Impacts of amino acid nutrition on pregnancy outcome in pigs: Mechanisms and implications for swine production1,2 3 G. Wu,* F. W. Bazer,* R. C. Burghardt,* G. A. Johnson,* S. W. Kim,† X. L. Li,* M. C. Satterfield,* and T. E. Spencer* *Departments of Animal Science and of Veterinary Integrative Biosciences, Texas AM University, College Station 77843; and †Department of Animal Science, North Carolina State University, Raleigh 27695 ABSTRACT: Pigs suffer up to 50% embryonic and thesis and angiogenesis. Additionally, arginine, leucine, fetal loss during gestation and exhibit the most severe glutamine, and proline activate the mammalian target naturally occurring intrauterine growth retardation of rapamycin cell-signaling pathway to enhance protein among livestock species. Placental insufficiency is a synthesis and cell proliferation in placentae. To trans- major factor contributing to suboptimal reproductive late basic research on AA biochemistry and nutrition performance and reduced birth weights of pigs. En- into application, dietary supplementation with 0.83% hancement of placental growth and function through l-arginine to gilts on d 14 to 28 or d 30 to 114 of ges- nutritional management offers an effective solution to tation increased the number and litter birth weight of improving embryonic and fetal survival and growth. We live-born piglets. In addition, supplementing the gesta- discovered an unusual abundance of the arginine fam- tion diet with 0.4% l-arginine plus 0.6% l-glutamine ily of AA in porcine allantoic fluid (a reservoir of nu- enhanced the efficiency of nutrient utilization, reduced trients) during early gestation, when placental growth