Avicel PH Microcrystalline Cellulose, NF, Ph Eur, JP, BP：微晶纤维素PH微晶纤维素，NF，欧洲药典，JP，BP.pdf

Section 11 Avicel® PH Microcrystalline Cellulose, NF, Ph Eur., JP, BP By Dr. George E. Reier Table of Contents Avicel Microcrystalline Cellulose1 Table of Contents1 Manufacturing Process 2 Importance of the Commercial Introduction of Avicel PH Microcrystalline Cellulose to Direct Compression 4 The Tableting Characteristics of Avicel Microcrystalline Cellulose5 A Comparison of Avicel Microcrystalline Cellulose Types and their Uses 7 Figure 3: PH-1017 Figure 4: PH-1028 Figure 5: PH-1038 Figure 6: PH-1059 Figure 7: PH-1129 Figure 8: PH-11310 Figure 9: PH-20010 Figure 10: PH-30111 Figure 11: PH-30211 Avicel PH Microcrystalline Cellulose Functionality in the Wet Granulation Manufacturing Process...12 Rapid, Even Wicking Action 12 Controls Wet Mass Consistency12 Less Screen Blocking 12 Uniform, Rapid Drying 12 Controls Color Mottling and Drug Content Uniformity12 Acts as an Auxiliary Binder 13 Avicel PH Microcrystalline Cellulose as a Spheronizing Agent 13 Editor’s Note14 Bibliography/Publications 15 1 Manufacturing Process In 1962, O. A. Battista and P. A. Smith obtained, the particle size distribution and reported the preparation by the American moisture content of which can be varied Viscose Company of microcrystalline cellu- through the spray drying process. lose from cellulose, hence the origin of the product name “Avicel”. The “PH” designa- The actual manufacturing process begins tion indicates that the product is suitable with specially selected rolls of wood pulp for pharmaceutical use. Cellulose is present that are diced, or cut, into small particles. in much of the food of man but is inert to These chopped particles are hydrolyzed human dige