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Authors’ conclusions Both wTCF and wTX are active regimens wTCF achieves high response rates and progression-free survival times comparable to 3-weekly TCF. wTCF has a more favourable safety profile and a lower rate of febrile neutropenia wTX has significant activity with minimal grade 3/4 toxicity and may be ideal for patients who are not suitable for platinum-based regimens Modification of wTCF by substitution of cisplatin with oxaliplatin (E) and 5-FU with capecitabine (X) to generate wTEX may further improve activity and safety. This combination is worthy of further study Key messag