胆碱受体阻断药PPT课件.pptVIP

Classification Base on specific receptor affinities Antimuscarinic agents Antinicotinic agents( consist of ganglion-blockers and neuromuscular junction blockers) Atropine and its alkaloids Atropine Anisodamine Acopolamine chemistry and pharmacokinetics Tertiary amine alkaloid esters of tropic acid Well absorbed from the gut and across the conjunctival membrane Widely distributed Metabolism and excretion Pharmacological Effects Glands Sweat, salivary gland secretion are greatly reduced Bronchial secretion decreased Reduction in gastric secretion and total acid content, especially at dose