氯吡格雷联合依达拉奉治疗急性脑梗死的临床疗效及安全性.doc

氯毗格雷联合依达拉奉治疗急性脑梗死 的临床疗效及安全性 马怡 重庆市合川区人民医院神经内科 R的探讨氯毗格雷联合依达拉奉治疗急性脑梗死的临床疗效及安全性。方法选 取重庆市合川区人民医院2016年2—11月收治的急性脑梗死患者96例，随机分 为对照组和联合用药组，各48例。对照组患者给予氯毗格雷治疗，联合用药组 患者在对照组基础上联合依达拉奉治疗，两组患者均持续治疗2周。比较两组患 者的临床疗效，治疗前后超敏C反应蛋白、白介素6 （TL-6）、血细胞比容、总 胆固醇水平及神经功能缺损评分、SF-36生活质量评分、口常生活活动能力（BI） 指数，观察患者不良反应发生情况。结果联合用药组患者治疗总有效率高于对 照组（P0.05）。治疗前，两组患者超敏C反应蛋白、1L-6、血细胞比容、总胆 固醇水平比较，差异无统计学意义（P0. 05）:治疗后，联合用药组患者超敏C 反应蛋白、IL-6、血细胞比容、总胆固醇水平低于对照组（P〈0.05）。治疗前，两 组患者神经功能缺损评分、SF-36生活质量评分、BI指数比较，差异无统计学意 义（P〉0.05）;治疗后，联合用药组患者神经功能缺损评分低于对照组，SF-36 生活质量评分、B1指数高于对照组（P0.05）。两组患者均未出现严重不良反 应。结论采用氯毗格雷联合依达拉奉治疗急性脑梗死的临床疗效确切，可有效 改善患者血脂、血液流变学，降低炎性反应，改善神经功能，提高患者的生活质 量和自理能力，且用药安全。 关键词： 脑梗死;氯毗格雷;依达拉奉;治疗结果;安全性; 2017-07-06 Clinical effect and the safety of clopidogrel combined with edaravone in the treatment of acute cerebral infarction MA Yi Department of Neurology, Hechuan District People’s Hospital， Chongqing; Abstract： Objective To investigate the clinical effect and the safety of clopidogrel combined with edaravone in the treatment of acute cerebral infarction. Methods A total of 96 cases of patients with acute cerebral infarction were selected from February to November in 2016 in Hechuan District People’s Hospital, which were randomly divided into control group and combined medication group, 48 cases in each group. The control group was treated with clopidogrel, and combined treatment group was treated with edaravone on the basis of control group, both groups were treated for two weeks. The clinical effect, high sensitivity C reactive protein, 1L_6, hematocrit, total cholesterol and neural function defect scores, SF-36 scores and BI index before and after treatment were compared between the two groups, and the medication safety was observed. Results The combined treatment group of total efficiency rate was higher than control group (P 0. 05) . Before treatment, no significant differences of high sensitivity C reactive protein, IL-6, hematocrit or total cholesterol was found between the two groups ( P 0. 05) ; after treat