治疗性降压疫苗研究进展演示文稿.pptVIP

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* * * Whether vaccine might be used to treat hypertension? * whether是否探索 * * millimeters of mercury]毫米汞柱 * * * mercury * According to data above, repeated immunization against a domain of the extracellular portion of the AT1 receptor is able to cause a target organ protection against hypertension. * * Therapeutic vaccines for hypertension 治疗性降压疫苗研究进展 Liao Yu-Hua, MD. Institute of Cardiology, Union hospital Huazhong University of Science Technology Wuhan, China Foshan, 2008 World Congress of Vaccine Renin-Angiotensin System involved in pathogenesis of hypertension Angiotensinogen Angiotensin I Angiotensin II ATR1 Vasoconstruction Volume retension ACE Renin Chemical Drugs Renin inhibitor ACEI angiotensin-converting enzyme inhibitor ARB Angiotensin receptor blocker Hypertension Foshan, 2008 World Congress of Vaccine UIC Union Institute of Cardiology A story:from autoantibodies of hypertension to vaccines of hypertension(HT) Autoantibodies in HT ? Autoimmune damage? Dangerous warning Pathogenesis of HT prevention and treatment of HT Safety signal Foshan, 2008 World Congress of Vaccine UIC Union Institute of Cardiology Evidences of autoantibodies against G-protein coupled receptor in patients with hypertension Prevalence of Anti AT1 receptor Ab Prevalence of Anti α1-adrenoceptor Ab Primary Hypertension total 26.8% (Liao,2002) 25.3% (Liao,2002) 44% (Luther,1997) refractory 42.9% (Liao,2002) 36.7% (Liao,2002) 78% (Homuth,2003) non-refractory 10.4% (Liao,2002) 13.5% (Liao,2002) Malignant Hypertension 14-33% (Fu,2000) 20% (Fu,1994) Secondary Hypertension 14% (Fu,2000) 64% (Fu,2000) Fu ML, et al.Lancet. 1994 ;344:1660-1663 Luther HP, et al. Hypertension. 1997;29:678-682 Fu ML, et al. J Hypertens. 2000;18:945-953 Liao YH, et al. Hypertens Res. 2002;25:641–646. Homuth V, et al. Hypertonie 2003 (online article ) Foshan, 2008 World Congress of Vaccine UIC Union Institute of Cardiology Arterial remodeling wa

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